Endocrine Abstracts

Obesity is usually considered to be a forerunner to insulin resistance (IR). Using in vitro studies, we have identified a role for the giant protein AHNAK in regulating Glut4 expression and function. Ex vivo analysis of white adipose tissue from ob/ob mice and aged/obese rats exhibited elevated AHNAK protein levels (2.3- and 3- fold) with concomitant reduction in Glut4 levels (5- and 2-fold).The aim of this study was to investigate the ...

Introduction: Non-islet cell tumour hypoglycaemia (NICTH) is an uncommon but serious complication of disseminated malignancy. The underlying aetiology of hypoglycaemia is tumoral overproduction of IGF2, which results in stimulation of insulin receptors and increased glucose utilization. Extensive tumour burden involving the liver and adrenal glands can also cause severe hypoglycaemia.Case report: An 80-year-old man presented acutely in an unresponsive st...